Table 3.
Genes in MutaMouse affected by potentially deleterious single nucleotide variants (as determined by SIFT) that are relevant to genetic toxicology studies.
| Gene Symbol | Number of SNVs in gene for each animal | Chromosomal position(s) and nucleotide change(s) | Amino acid change (codon change) | Proteina | Functions | ||||
|---|---|---|---|---|---|---|---|---|---|
| HC 1 | HC 2 | HC 3 | HC 4 | HC 5 | |||||
| Ahr | 1 | 1 | 1 | 1 | 1 | chr12:35508182 T > C | I/V (Atc/Gtc) | Aryl hydrocarbon receptor | Xenobiotic metabolism, Cell cycle |
| Arpp19 | 1 | 1 | 1 | 1 | 1 | chr9:75056711 C > G | P/R (cCg/cGg) | cAMP-regulated phosphoprotein 19 | Cell cycle |
| Cbl | 0 | 0 | 0 | 1 | 2 |
chr9:44151504 C > T, chr9:44151527 A > T |
A/T (Gct/Act), I/N (aTt/aAt) |
E3 ubiquitin-protein ligase CBL | Cancer progression |
| Ccnb2 | 0 | 0 | 0 | 1 | 0 | chr9:70410215 G > A | T/M (aCg/aTg) | G2/mitotic-specific cyclin-B2 | Cell cycle |
| Ccnb3 | 1 | 1 | 1 | 1 | 1 | chrX:7025679 T > A | N/I (aAc/aTc) | G2/mitotic-specific cyclin-B3 | Cell cycle |
| Cdc5l | 0 | 0 | 1 | 0 | 0 | chr17:45407947 G > A, | T/M (aCg/aTg) | Cell division cycle 5-like protein | DNA repair, Cell cycle |
| Cdk4 | 0 | 0 | 1 | 0 | 1 | chr10:127064302 G > A | A/T (Gcc/Acc) | Cyclin-dependent kinase 4 | Cancer progression, Cell cycle |
| Cenpt | 0 | 0 | 0 | 1 | 0 | chr8:105845366 G > A | R/C (Cgc/Tgc) | Centromere protein T | Cell cycle |
| Eif4a2 | 0 | 0 | 2 | 2 | 0 |
chr16:23113181 G > T, chr16:23113194 G > T |
G/V (gGt/gTt), R/S (agG/agT) |
Eukaryotic initiation factor 4A-II | Cancer progression |
| Hsp90ab1 | 0 | 1 | 9 | 9 | 1 |
chr17:45568279 T > A, chr17:45568347 T > G, chr17:45568434 C > T, chr17:45568456 T > C, chr17:45568465 G > A, chr17:45568474 T > G, chr17:45568484 G > A, chr17:45568493 T > C, chr17:45568520 C > T, chr17:45568531 G > T, chr17:45568532 G > A |
D/V (gAt/gTt), K/N (aaA/aaC), M/I (atG/atA), D/G (gAc/gGc), A/V (gCa/gTa), K/T (aAg/aCg), R/W (Cgg/Tgg), N/D (Aac/Gac), V/M (Gtg/Atg), P/H (cCc/cAc), P/S (Ccc/Tcc) |
Heat shock protein HSP 90-beta | Cancer progression |
| Mapk6 | 1 | 1 | 1 | 1 | 1 | chr9:75388680 T > A | Q/L (cAg/cTg) | Mitogen-activated protein kinase 6 | Cell cycle |
| Mplkip | 2 | 2 | 2 | 2 | 2 |
chr13:17695605 C > T, chr13:17695681 C > A |
R/W (Cgg/Tgg), P/Q (cCg/cAg) |
M-phase-specific PLK1-interacting protein | Cell cycle |
| Msi2 | 1 | 1 | 1 | 1 | 1 | chr11:88687461 C > A | V/F (Gtc/Ttc) | RNA-binding protein Musashi homolog | Cancer progression |
| Nabp2 | 0 | 1 | 0 | 0 | 1 | chr10:128408557 C > T | G/S (Ggc/Agc) | SOSS complex subunit B1 | DNA repair, Cell cycle |
| Nanog | 1 | 0 | 1 | 1 | 0 | chr6:122707814 T > G | L/W (tTg/tGg) | Homeobox protein | Cell cycle |
| Nek1 | 1 | 1 | 1 | 1 | 1 | chr8:61054575 C > A | R/S (Cgt/Agt) | Serine/threonine-protein kinase | Cell cycle |
| Rev1 | 0 | 2 | 0 | 2 | 0 |
chr1:38088013 T > C, chr1:38088020 C > G |
K/E (Aaa/Gaa), K/N (aaG/aaC) |
DNA repair protein REV1 | DNA repair |
| Rprd1b | 0 | 1 | 0 | 0 | 0 | chr2:158047932 G > T | K/N (aaG/aaT) | Regulation of nuclear pre-mRNA domain-containing protein 1B | Cell cycle |
| Rrs1 | 13 | 12 | 13 | 13 | 13 |
chr1:9545597 C > T, chr1:9545621 A > T, chr1:9545666 C > T, chr1:9545674 C > T, chr1:9545762 C > A, chr1:9545801 C > A, chr1:9545860 C > A, chr1:9545917 G > C, chr1:9545925 C > A, chr1:9546313 G > A, chr1:9546338 T > A, chr1:9546341 G > T, chr1:9546377 C > T |
T/M (aCg/aTg), E/V (gAg/gTg), T/I (aCc/aTc), R/C (Cgc/Tgc), P/Q (cCg/cAg), P/Q (cCg/cAg), R/S (Cgc/Agc), V/L (Gtg/Ctg), D/E (gaC/gaA), E/K (Gag/Aag), L/H (cTt/cAt), R/L (cGa/cTa), T/M (aCg/aTg) |
Ribosome biogenesis regulatory protein homolog | Cell cycle |
| Tdpoz2 | 1 | 1 | 1 | 1 | 1 | chr3:93652273 G > C | L/V (Ctc/Gtc) | TD and POZ domain-containing protein 2 | Cancer progression |
| Thrap3 | 3 | 1 | 3 | 3 | 3 |
chr4:126165462 T > C, chr4:126165536 G > A, chr4:126165542 G > A |
I/M (atA/atG), R/W (Cgg/Tgg), R/W (Cgg/Tgg) |
Thyroid hormone receptor-associated protein 3 | Cancer progression |
| Tjp3 | 0 | 0 | 1 | 0 | 0 | chr10:81274478 T > G | (Atc/Ctc) | Tight junction protein ZO-3 | Cell cycle |
| Total | 29 | 32 | 46 | 45 | 32 | ||||
aPanther protein family/subfamily or class.