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. 2019 Sep 24;10:4329. doi: 10.1038/s41467-019-11954-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Heritability of lipidomic profiles and genetic correlations among the lipid species. a Histogram and kernel density curve showing the distribution of heritability estimates across all the lipid species. b Boxplot showing the heritability estimates in each lipid class. c Boxplot showing comparison of the median heritability estimates of lipid species containing C20:4, C20:5 and C22:6 acyl chains and all others. The P-values were calculated using the Wilcoxon rank-sum test. d Hierarchical clustering of lipid species based on genetic correlations among lipid species. Lipids containing polyunsaturated fatty acids C20:5, C20:4 and C22:6 are highlighted with black bars. The data presented in the boxplots represent the interquartile range (IQR) defined by the bounds of the box with the median (middle line of the box) and whiskers extending to the largest/smallest values no further than 1.5 times the IQR. CER ceramide, DAG diacylglyceride, LPC lysophosphatidylcholine, LPE lysophosphatidylethanolamine, PC phosphatidylcholine, PCO phosphatidylcholine-ether, PE phosphatidylethanolamine, PEO phosphatidylethanolamine-ether, PI phosphatidylinositol, CE cholesteryl ester, SM sphingomyelin, ST sterol, TAG triacyglycerol, Trad traditional lipids