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. 2019 Sep 24;6:179. doi: 10.1038/s41597-019-0185-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overview of the experimental procedure. The tibial nerve, the largest branch of the sciatic nerve, supplies the gastrocnemius muscle and other muscles of the lower limb posterior compartment. In our mouse model of denervation atrophy, the sciatic nerve is identified, and its branches separated to isolate the tibial nerve (a; nerve identities are as follows: 1, sural nerve; 2, tibial nerve; 3, common peroneal/fibular nerve; 4, sciatic nerve). We generated a cohort of C57BL/6 J male mice denervated for 0, 1, 3, 7, 14, 30, or 90 days (b,c). Significant atrophy is apparent by 7 days after denervation, with consistent decline in mass during chronic denervation (d); ***P < 0.001 compared to baseline.