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. 2019 Sep 24;9:13748. doi: 10.1038/s41598-019-50141-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential iodoacetate effects on cell cycle progression and repair genes expressions in MCF-7 and MDA-MB-231 cells. (A) Representative DNA histograms displaying various cell cycle phases for MCF7 and MDA-MB-231 4 and 12 h after treatment with 15 mM IA. (B) Quantification of percentage cell death (sub G1) induced by various [IA] for 4 and 12 h. (C) Bar chart representing the percentage of cell population in MCF7 and MDA-MB-231 after IA treatment at (0–20 µM) for 4 and 12 hrs. (D–I) mRNA expression for both MCF7 (upper row) and MDA-MB-231 (lower row) for p21 (D,G), p27 (E,H), and PARP-1 (F,I). Quantification was carried out over three independent runs. Statistical analyses were carried out using One-way ANOVA where statistical significance was achieved at p < 0.05.