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. 2019 Sep 24;9:13748. doi: 10.1038/s41598-019-50141-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analyses of differential metabolic effects of IA on bioenergetic parameters in MCF7 and MDA-MB-231 cells. Effects of pre-incubation of the two cell types with 5, 10, or 20 mM IA for 4 (A) or 12 h (B) on glycolytic as well as mitochondrial bioeneregetic parameters as determined by glycolytic stress tests (probed through ECAR) and mitochondrial stress test (probed through OCR). Results are representative of at least 3 independent runs performed using Seahorse XF metabolic flux analyzer as detailed in the methods section. (C) Quantification of basal rates (OCR and ECAR) for MCF7 and MDA-MB-231 pretreated with IA at concentrations of 0, 5, 10, or 20 μM for 4 h or 12 h.