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. 2019 Sep 24;10:4336. doi: 10.1038/s41467-019-12313-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Near infrared (NIR)-activated TRIDENT for antibiotic-resistant bacteria killing. The prepared thermo-responsive-inspired drug-delivery nano-transporter (TRIDENT, also named IMP/IR780@TRN) is “melted” when the temperature rises to above 43 °C under the NIR irradiation, leading to the release of imipenem to the infected site. Consequently, the multidrug-resistant bacteria can be efficiently damaged through a synergistic antibiotic-photothermal strategy with a relatively low dosage of antibiotic, eventually accelerating the recovery of the infected skin