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. 2019 Sep 24;9:13759. doi: 10.1038/s41598-019-50256-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The miRNA-based network dysregulated in the PD. The orange nodes represent miRNAs, the yellow nodes represent the target genes, and the blue ones show the transcription factors (TFs); on the other hand, the green ones represent molecules that are TFs and also, the target genes. The red edges show the TF-miRNA feedback loops (FBLs).