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. 2019 Sep 24;9:13759. doi: 10.1038/s41598-019-50256-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The nodes and edges involved in the feedback loops of the miRNA-based network. Orange nodes represent miRNAs, and the green ones show the molecules that are TFs and also, the target genes. Confidence level of TF-miRNA regulations is based on the TransmiR database. Regarding miRNA-target interactions, we also assumed that all miRNAs repressed their targets.