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. 2019 Sep 24;9:13759. doi: 10.1038/s41598-019-50256-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene Ontology (GO) and pathway enrichment analysis. (A–C) GO enrichment analysis was summarized and visualized as a scatter plot using REVIGO²⁸. Scatter plot was generated in REVIGO by clustering the significant (adjusted p-value < 0.05) GO terms remaining after redundancy reduction for the biological processes (A), molecular functions (B) and cellular components (C) in a two-dimensional space (2D space), according to semantic similarities. The bubble color indicates -log₁₀ (adjusted p-value) according to the legend. Bubble size refers to the frequency of the GO term in the underlying Homo sapiens database. Cluster representatives with the lowest dispensability value are labelled. (D) The bar plot shows −log₁₀ (adjusted p-value) of the significantly enriched PANTHER pathways (adjusted p-value < 0.001) for all nodes of the microRNA-based network. Fold enrichment for each pathway is shown in parentheses as the percentage.