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. 2019 Sep 24;9:13764. doi: 10.1038/s41598-019-50205-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intermediates of NO metabolism in study population with respect to dementia pathology: (a) arginine; (b) ADMA; (c) SDMA; (d) citrulline; (e) DMA; (f) Arg/ADMA. Data analyzed using analysis of covariance (ANCOVA) with age as a covariate either in a whole population with significance of age (A) and group (G) effect marked with “1” in superscript. The same analysis was repeated exclusively on dementia patients and the significance of age and group effects was marked as “2” in superscript. Geometric mean values are presented graphically by inverse triangles and 95% confidence interval around mean by whiskers. C-B, controls: blood donors; C-H, controls: non-demented patients; D-A, Alzheimer disease; D-M, mixed-type dementia; D-V, vascular dementia. *p < 0.05; **p < 0.01; ***p < 0.001 (for whole cohort analysis); ^##p < 0.01 (for dementia cohort analysis).