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. Author manuscript; available in PMC: 2019 Sep 25.
Published in final edited form as: Head Neck. 2017 Sep 30;40(2):233–241. doi: 10.1002/hed.24938

TABLE 1.

Dose escalation scheme

Dose level Afatinib, oral on d 1-21 of each 21-d cycle Ribavirin, oral on d 1-21 of each 21-d cycle Paclitaxel, intravenously on d 1 and 8 of each 21-d cycle Carboplatin, intravenously on d 1 and 8 of each 21-d cycle
1 30 mg/d Weight baseda 80 mg/m2 AUC 1.5b
2 40 mg/d Weight baseda 80 mg/m2 AUC 1.5b

Abbreviation: AUC, area under the curve.

a

Patients who weighed ≤75 kg received ribavirin 400 mg orally in the morning and 600 mg orally in the evening and patients who weighted >75 kg received 600 mg orally twice daily.

b

The dose of carboplatin could not exceed a flat dose of 225 mg.