TABLE 1.
Dose level | Afatinib, oral on d 1-21 of each 21-d cycle | Ribavirin, oral on d 1-21 of each 21-d cycle | Paclitaxel, intravenously on d 1 and 8 of each 21-d cycle | Carboplatin, intravenously on d 1 and 8 of each 21-d cycle |
---|---|---|---|---|
1 | 30 mg/d | Weight baseda | 80 mg/m2 | AUC 1.5b |
2 | 40 mg/d | Weight baseda | 80 mg/m2 | AUC 1.5b |
Abbreviation: AUC, area under the curve.
Patients who weighed ≤75 kg received ribavirin 400 mg orally in the morning and 600 mg orally in the evening and patients who weighted >75 kg received 600 mg orally twice daily.
The dose of carboplatin could not exceed a flat dose of 225 mg.