Table 1.
Pretest Differences Between Genotype Groups
| Variablea | Asn40Asn (n=18) | Asn40Asp/Asp40Asp (n=23) | Test for Difference |
|---|---|---|---|
| Gender | χ2 (1) = .146, p = 0.702 | ||
| Female (%) | 6 (33%) | 9 (39%) | |
| Male (%) | 12 (67%) | 14 (61%) | |
| Ethnicity | Fisher’s exact test, p = 0.20 | ||
| Chinese (%) | 8 (44%) | 7 (30%) | |
| Japanese (%) | 0 (0%) | 3 (13%) | |
| Korean (%) | 7 (39%) | 12 (52%) | |
| Taiwanese (%) | 3 (17%) | 1 (4%) | |
| ALDH2b | Fisher’s exact test, p = 0.21 | ||
| *I/*I (%) | 17 (94%) | 18 (78%) | |
| *I/*2 (%) | 1 (6%) | 5 (22%) | |
| *2/*2 (%) | 0 (0%) | 0 (0%) | |
| ADH1Bb | Fisher’s exact test, p = 0.99 | ||
| *I/*I (%) | 8 (44%) | 11 (48%) | |
| *I/*2 (%) | 8 (44%) | 9 (39%) | |
| *2/*2 (%) | 2 (11%) | 3 (13%) | |
| Agec | 30.17 (8.61) | 26.78 (5.00) | t(39) = 1.58, p = 0.12 |
| AUDd | Fisher’s exact test, p = 0.57 | ||
| None | 9 (50%) | 9 (39%) | |
| Mild | 5 (28%) | 11 (48%) | |
| Moderate | 2 (11%) | 2 (9%) | |
| Severe | 2 (11%) | 1 (4%) | |
| AUDITe | 15.39 (4.89) | 13.74 (5.41) | t(39) = 1.01, p = 0.32 |
| Drinking Daysf | 15.78 (7.49) | 12.00 (5.33) | t(39) = 1.89, p = 0.07 |
| Drinks/Drinking Dayf | 5.38 (2.78) | 4.32 (1.75) | t(39) = 1.48, p = 0.15 |
| Marijuana Daysf | 1.50 (2.64) | 2.17 (4.91) | t(39) = −0.53, p = 0.60 |
| PLAC Days since Drinkf | 1.83 (1.10) | 2.78 (1.78) | t(39) = 1.98, p = 0.06 |
| NTX Days since Drinkf | 2.33 (1.53) | 3.26 (1.66) | t(39) = −1.84, p = 0.07 |
| PLAC pre-scan AUQ | 8.11 (6.06) | 7.53 (5.39) | t(39) = 0.33, p = 0.77 |
| NTX pre-scan AUQ | 5.94 (6.46) | 5.53 (5.64) | t(39) = 0.20, p = 0.84 |
a
Standard deviations appear within parentheses for continuous variables.
b
*I/*I = GG, *I/*2= AG, *2/*2 = AA.
c
Assumption of homogeneity of variance not met, adjusted degrees of freedom, t-statistic, and significance level accounted for within table.
d
Current (past 3 months) Alcohol Use Disorder (AUD) assessed by the Structure Clinical Interview for Alcohol Use Disorder (DSM-5).
e
Alcohol Use Disorder Identification Test (AUDIT) score > 8 indicates hazardous drinking pattern; possible range of scale: 0 – 40.
f
Assessed by Timeline Follow Back (TLFB) interview for the past 30 days