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The rate of formation of imidaprilat (nmol/mg/min) resulting from the incubation of imidapril with 160 µg/ml human hepatic carboxylesterase (hCE1b) for 60 min. The Michaelis constant (Km) and the maximal reaction velocity (Vmax) were obtained from nonlinear regression analysis in GraphPad Prism 7 (see Supplementary Material for model equation). The experiment was run in duplicate and each point depicts mean ± SEM.
