Table 1.
Genomic Location, Sequence, and Biological Relevance of Selected miRNAs
| miRNAs (miRBase ID) | Genomic Location | miRNA Sequence | Related Roles/Functions |
|---|---|---|---|
| hsa-miR‒517-5pa | 19: 53721076-53721142 [+] | 5′-CCUCUAGAUGGAAGCACUGUCU-3′ | Trophoblast cell proliferation, conferment of viral resistance to nonplacental maternal cell (28, 29) |
| hsa-miR‒517a-3pa | 19: 53712268-53712354 [+] | 5′-AUCGUGCAUCCCUUUAGAGUGU-3′ | |
| +hsa-miR-518ba | 19: 53702737-53702819 [+] | 5′-CAAAGCGCUCCCCUUUAGAGGU-3′ | |
| hsa-miR-520ha | 19: 53742512-53742599 [+] | 5′-ACAAAGUGCUUCCCUUUAGAGU-3′ | |
| hsa-miR‒525-5pa | 19: 53697533-53697617 [+] | 5′-CUCCAGAGGGAUGCACUUUCU-3′ | |
| hsa-miR-1323a | 19: 53671968-53672040 [+] | 5′-UCAAAACUGAGGGGCAUUUUCU-3′ | |
| hsa-miR‒136-5pb | 14: 100884702-100884783 [+] | 5′-ACUCCAUUUGUUUUGAUGAUGGA-3′ | Cellular proliferation, migration, and invasion (29, 30) |
| hsa-miR‒342-3pb | 14: 100109655-100109753 [+] | 5′-UCUCACACAGAAAUCGCACCCGU-3′ | |
| hsa-miR‒376c-5pb | 14: 101039690-101039755 [+] | 5′-GGUGGAUAUUCCUUCUAUGUU-3′ | |
| hsa-miR‒494-3pb | 14: 101029634-101029714 [+] | 5′-AGGUUGUCCGUGUUGUCUUCUCU-3′ | |
| hsa-miR‒29a-3p | 7: 130212046 - 130212109 [−] | 5′-UAGCACCAUCUGAAAUCGGUUA-3′ | Modulation of angiogenic properties of human endothelial cells (31), upregulated in β cells by glucose, and decreased glucose-stimulated insulin secretion (22, 34) |
| hsa-miR‒29b-3p | 7: 130212758 - 130212838 [−] | 5′-UAGCACCAUUUGAAAUCAGUGUU-3′ | Apoptosis, invasion and angiogenesis of trophoblast cells (32), and insulin-stimulated glucose uptake (33) |
| hsa-miR‒122-5p | 18: 54269286 - 54269370 [+] | 5′-UGGAGUGUGACAAUGGUGUUUG-3′ | Vascular inflammation and diabetes (34) |
| hsa-miR‒132-3p | 17: 2049908-2050008 [−] | 5′-UAACAGUCUACAGCCAUGGUCG-3′ | Dyslipidemia and diabetes (23) |
| hsa-miR‒182-3p | 7: 129770383-129770492 [−] | 5′-UGGUUCUAGACUUGCCAACUA-3′ | Type 2 diabetes pathogenesis (35), insulin resistance, and coronary artery disease (36, 37) |
| hsa-miR‒210-3p | 11: 568089-568198 [−] | 5′-CUGUGCGUGUGACAGCGGCUGA-3′ | Hypoxia, insulin resistance (38), and antiangiogenesis (29, 39) |
| hsa-miR‒483-3p | 11: 2134134-2134209 [−] | 5′-UCACUCCUCUCCUCCCGUCUU-3′ | Insulin resistance, onset diabetes mellitus, and cardiovascular disease (40) |
a
miRNAs belonging to the chromosome 19 miRNA cluster, which are placenta-specific miRNAs.
b
miRNAs belonging to the chromosome 14 miRNA cluster, which are pregnancy-related miRNAs highly expressed in the placenta.