Table 7.
Lifetime Prevalence of Metabolic Involvement and Organ Abnormalities by Country
| United States | Turkey | Brazil | Overall | |
|---|---|---|---|---|
| (a) GL and PL | n = 98 | n = 80 | n = 52 | N = 230 |
| Diabetes and/or IR | 71 (72.4) | 48 (60.0) | 15 (28.8) | 134 (58.3) |
| One or more elevated laboratory values | 89 (90.8) | 69 (86.3) | 51 (98.1) | 209 (90.9) |
| Tg >150 mg/dL | 79 (80.6) | 63 (78.8) | 48 (92.3) | 190 (82.6) |
| Tg >500 mg/dL | 30 (30.6) | 37 (46.3) | 26 (50.0) | 93 (40.4) |
| HbA1c >5.7% | 55 (56.1) | 51 (63.8) | 37 (71.2) | 143 (62.2) |
| HbA1c >6.5% | 42 (42.9) | 42 (52.5) | 30 (57.7) | 114 (49.6) |
| ALT >35 U/L | 62 (63.3) | 40 (50.0) | 38 (73.1) | 140 (60.9) |
| ALT >55 U/L | 34 (34.7) | 27 (33.8) | 27 (51.9) | 88 (38.3) |
| AST >35 U/L | 47 (48.0) | 31 (38.8) | 34 (65.4) | 112 (48.7) |
| AST >48 U/L | 29 (29.6) | 20 (25.0) | 24 (46.2) | 73 (31.7) |
| One or more organ abnormalities | 76 (77.6) | 69 (86.3) | 37 (71.2) | 182 (79.1) |
| Liver abnormalities | 61 (62.2) | 67 (83.8) | 37 (71.2) | 165 (71.7) |
| Kidney abnormalities | 26 (26.5) | 42 (52.5) | 25 (48.1) | 93 (40.4) |
| Heart abnormalities | 37 (37.8) | 21 (26.3) | 12 (23.1) | 70 (30.4) |
| Pancreatitis | 12 (12.2) | 15 (18.8) | 3 (5.8) | 30 (13.0) |
| (b) GL subgroup | n = 24 | n = 32 | n = 25 | N = 81 |
| Diabetes and/or IR | 18 (75.0) | 18 (56.3) | 11 (44.0) | 47 (58.0) |
| One or more elevated laboratory values | 21 (87.5) | 30 (93.8) | 24 (96.0) | 75 (92.6) |
| Tg >150 mg/dL | 18 (75.0) | 26 (81.3) | 22 (88.0) | 66 (81.5) |
| Tg >500 mg/dL | 10 (41.7) | 20 (62.5) | 11 (44.0) | 41 (50.6) |
| HbA1c >5.7% | 8 (33.3) | 18 (56.3) | 17 (68.0) | 43 (53.1) |
| HbA1c >6.5% | 5 (20.8) | 16 (50.0) | 14 (56.0) | 35 (43.2) |
| ALT >35 U/L | 16 (66.7) | 22 (68.8) | 22 (88.0) | 60 (74.1) |
| ALT >55 U/L | 9 (37.5) | 18 (56.3) | 16 (64.0) | 43 (53.1) |
| AST >35 U/L | 14 (58.3) | 18 (56.3) | 18 (72.0) | 50 (61.7) |
| AST >48 U/L | 7 (29.2) | 13 (40.6) | 13 (52.0) | 33 (40.7) |
| One or more organ abnormalities | 22 (91.7) | 31 (96.9) | 21 (84.0) | 74 (91.4) |
| Liver abnormalities | 19 (79.2) | 31 (96.9) | 21 (84.0) | 71(87.7) |
| Kidney abnormalities | 9 (37.5) | 18 (56.3) | 17 (68.0) | 44 (54.3) |
| Heart abnormalities | 12 (50.0) | 10 (31.3) | 6 (24.0) | 28 (34.6) |
| Pancreatitis | 2 (8.3) | 5 (15.6) | 1 (4.0) | 8 (9.9) |
| (c) PL subgroup | n = 74 | n = 48 | n = 27 | N = 149 |
| Diabetes and/or IR | 53 (71.6) | 30 (62.5) | 4 (14.8) | 87 (58.4) |
| One or more elevated laboratory values | 68 (91.9) | 39 (81.3) | 27 (100.0) | 134 (89.9) |
| Tg >150 mg/dL | 61 (82.4) | 37 (77.1) | 26 (96.3) | 124 (83.2) |
| Tg >500 mg/dL | 20 (27.0) | 17 (35.4) | 15 (55.6) | 52 (34.9) |
| HbA1c >5.7% | 47 (63.5) | 33 (68.8) | 20 (74.1) | 100 (67.1) |
| HbA1c >6.5% | 37 (50.0) | 26 (54.2) | 16 (59.3) | 79 (53.0) |
| ALT >35 U/L | 46 (62.2) | 18 (37.5) | 16 (59.3) | 80 (53.7) |
| ALT >55 U/L | 25 (33.8) | 9 (18.8) | 11 (40.7) | 45 (30.2) |
| AST >35 U/L | 33 (44.6) | 13 (27.1) | 16 (59.3) | 62 (41.6) |
| AST >48 U/L | 22 (29.7) | 7 (14.6) | 11 (40.7) | 40 (26.8) |
| One or more organ abnormalities | 54 (73.0) | 38 (79.2) | 16 (59.3) | 108 (72.5) |
| Liver abnormalities | 42 (56.8) | 36 (75.0) | 16 (59.3) | 94 (63.1) |
| Kidney abnormalities | 17 (23.0) | 24 (50.0) | 8 (29.6) | 49 (32.9) |
| Heart abnormalities | 25 (33.8) | 11 (22.9) | 6 (22.2) | 42 (28.2) |
| Pancreatitis | 10 (13.5) | 10 (20.8) | 2 (7.4) | 22 (14.8) |
Data are n (%) unless otherwise noted.
Abbreviations: IR, insulin resistance; Tg, triglycerides.