Table 1.
Phenotypic Comparison of GH−/− and GHR−/− Mice
| GH−/− | GHR−/−a | |
|---|---|---|
| Human disorder equivalent | IGHD type IA | Laron syndrome |
| Gene disrupted | Gh | Ghr |
| GH | Not detected | ↑ |
| IGF-1 | ↓ | ↓ |
| Fasting blood glucose levels | ↓ | ↓ |
| Fasting insulin levels | ↓ | ↓ |
| ITT result | ↑ | ↑ |
| GTT result | ↓ | ↓ |
| Pancreatic islet size | ↓ | ↓ |
| Adiposity (% body fat) | ↑ | ↑ |
| FFA levels | ↑ | ↑ |
| Liver triglyceride levels | ↑ | ↑ |
| WAT depot most enlarged | SC | SC |
| Adipocyte size | ||
| SC | ↑ | ↑ |
| Visceral (perigonadal) | ↔ | ↔ |
| Lifespan | ? | ↑ |
Abbreviations: ↑ increased; ↓ decreased; ↔ unchanged; ?, unknown; FFA, free fatty acid; IGHD, isolated GH deficiency; SC, subcutaneous.
aData from GHR−/− mice were reviewed in List et al. (5).