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Nonmeasureable lesions are those <10 mm in diameter either uni- or bi-dimensionally measured (A). Lesions (arrows) with margins that are not clearly defined and that blend in with brain tissue (B and C), a cystic lesion (D), leptomeningeal dissemination (E, arrow), and nonenhancing lesions on FLAIR and T2 imaging (F) should also be characterized as nonmeasureable lesions.
