Table 1.
A Summary of some tumor suppressor miRNAs and their target genes
| miRNA | Cancer type (Reference No.) | Involved pathway | Target gene |
|---|---|---|---|
| miR-1 | Ovarian cancer (136) | Proliferation and invasion | c-Met |
| miR-7 | Lung cancer (137) | Tumor Growth | TTF-1 |
| miR-7 | Hepatocarcinoma (138) | Proliferation and invasion | KLF-4 |
| miR-9-3p | Nasopharynx carcinoma (139) | EMT | FN1,ITGB1 and ITGAV |
| miR-17-5p | Non-small cell lung cancer (140) | Proliferation and apoptosis | TGFβR2 |
| miR-29a/b/c | Glioma (141) | Invasion | CDC42 |
| miR-30 | Lung cancer (142) | EMT | Snail |
| miR-31 | Gastric cancer (143) | Metastasis | RhoA |
| miR-33a | Melanoma (144) | Angiogenesis | HIF-1α |
| miR-34a | Bladder cancer (145) | Proliferation and invasion | HNF4G |
| miR-99a | Cervical carcinoma (146) | Proliferation | TRIB2 |
| miR-100 | Esophageal carcinoma (147) | Tumor growth | CXCR7 |
| miR-107-5p | Non-small cell lung cancer (148) | Tumor growth | EGFR |
| miR-126 | Esophageal cancer (149) | Proliferation | VEGF-A |
| miR-141-3p | Prostate cancer (150) | Bone metastasis | NF-κB |
| miR-143 | Breast cancer (151) | Tumor growth | ERK5,MAP3K7 |
| miR-145-3p | Non-small cell lung cancer (152) | Migration and invasion | PDK1 |
| miR-148a | Renal cell carcinoma (153) | Proliferation and invasion | AKT2 |
| miR-195 | Laryngeal carcinoma (154) | Tumor growth and invasion | DCUN1D1 |
| miR-203 | Hepatocellular carcinoma (155) | Metastasis | RASAL2 |
| miR-211-5p | Thyroid cancer (156) | Proliferation and invasion | SOX 11 |
| miR-429 | Hepatocellular carcinoma (157) | Migration and invasion | CRKL |
| miR-551b | Gastric cancer (158) | EMT and metastasis | ERBB4 |