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. 2019 Sep 24;9:13755. doi: 10.1038/s41598-019-50253-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Case probability of patients with early therapeutic intervention in Lac delta per min groups. There was a significant difference in case probability between the negative Lac delta per min group (n = 249) and the positive Lac delta per min group (n = 186) (A *P = 0.019 with the chi-square test). In quintile subgroups of the positive Lac delta per min group, the case probability was significantly increased with increasing Lac delta per min (B **P < 0.0001 with the Cochran-Armitage test).