Skip to main content
. 2018 Oct 22;26(5):128–135. doi: 10.1038/s41417-018-0051-0

Fig. 5. Cytotoxic effect of single-RRV or dual-RRV prodrug activator gene therapy after RRV infection in vitro.

Fig. 5

 The cell viabilities of RRV-pretransduced Hep3B cells on day 3 after exposure to 5FC (mM) and GCV (μM) were evaluated by the Alamar Blue assay. Data shown are means ± SD from triplicate experiments. The combination groups for infection were CD and CD (a), TK and TK (b), and CD and TK (c, d). N: No infection; Ca: AMLV-CD; Cg: GALV-CD; Ca + Cg: AMLV-CD + GALV-CD; Ta: AMLV-TK; Tg: GALV-TK; Ta + Tg: AMLV-TK + GALV-TK; Ca + Tg: AMLV-CD + GALV-TK; Cg + Ta: GALV-CD + AMLV-TK. IC50 values were shown in parentheses. *P < 0.05 (combination vs. any single)