Fig. 3.

Distinct direct AR target genes are regulated in ETS+ and ETS− PCa tumors. a Schematic of pipeline used to define 5 categories from the 131 direct AR transcription targets in ETS+ and ETS− PCa tumors. b Examples of genes whose expression is significantly different in adjacent normal tissue (N) in ETS+ PCa or ETS− PCa. c Heatmap of differentially expressed direct AR target genes in ETS- Up pink, ETS- Down gray, ETS+ Up blue, ETS+ Down green, and that are upregulated in both ETS+ and ETS− PCa (brown). Each row/gene is normalized to median expression in adjacent normal tissue. The 8 subtypes of ETS+ and ETS− PCa, as defined by their expression of ERG, ATV1, ETV4, FLI1, SPOP, FOXA1, IDH1 and “other” are shown beneath the heatmap