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. 2019 Jun 3;99(9):1309–1320. doi: 10.1038/s41374-019-0263-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Co-overexpression of MDM2 and CDK4 blocks differentiation during the complete adipogenic process. a, c The ability to differentiate into adipocytes was evaluated by Oil Red O staining. b, d mRNA expression levels of SREBP1, C/EBPβ, C/EBPα, PPARγ, ADIPSIN, and LPL were quantified by quantitative RT-PCR after the induction of adipogenesis for 21 days. The ratio of the expression levels of the genes to those of HPRT1 was used to determine the relative levels of all genes. 2H cells (a, b) and 5H cells (c, d)