Table 6.
Analysis of 22C3 tumor proportion score (TPS) groups
| Tumor typea | Search parameter | Number of cases | Average age, years | M:F | QNS % | Negative ( < 1%) | Expressed (1-49%) | Highly expressed ( = > 50%) |
|---|---|---|---|---|---|---|---|---|
| All cases | 52,585 | 68.9 | 51:49 | 3.6 | 33.1 | 33.9 | 29.5 | |
| Brain | “astrocytoma” or “glioblastoma” or “gbm” | 82 | 56.4 | 49:33 | 1.2 | 42.7 | 37.8 | 18.3 |
| Breast | “breast” or “lobular” or [“ductal” not “pancreatic”] | 737 | 61.3 | 0:737 | 3.7 | 58.2 | 27.5 | 10.6 |
| Colon | “colon” or “colonic” or “sigmoid” or “rectum” | 1142 | 64.3 | 321:521 | 1.9 | 66.6 | 26.2 | 5.3 |
| Endometrial | “endometrium” or “endometrial” or “uterus” | 258 | 63.5 | 0:258 | 3.1 | 54.7 | 38.0 | 4.3 |
| Esophageal | “esophageal” or “esophagus” or “GEJ” or “gastroesophageal” | 384 | 66.8 | 288:96 | 2.9 | 47.9 | 36.7 | 12.5 |
| Gastric | “gastric” or “stomach” or “pyloric” or “antrum” or “cardia” | 545 | 64.5 | 305:240 | 3.9 | 45.9 | 30.3 | 20.0 |
| Gastrointestinal stromal tumor | [“gastrointestinal” and “stroma”] or “GIST” | 42 | 65.0 | 24:18 | 2.4 | 50.0 | 45.2 | 2.4 |
| Hodgkin lymphoma | “Hodgkin” and “lymphoma” not [“NHL” or “non”] | 12 | 58.8 | 5:7 | 8.3 | 41.7 | 16.7 | 33.3 |
| Lung | [“lung” and “origin”] or [“lung” and “primary”] or [“non” and “small” and “cell”] or [“lepidic”] or [“pulmonary” and “origin”] or [“bronchogenic”] or [“NSCLC”] | 1695 | 69.7 | 819:876 | 3.9 | 25.9 | 33.7 | 36.5 |
| Melanoma | “melanoma” | 555 | 66.8 | 343:212 | 3.2 | 40.7 | 42.0 | 14.0 |
| Mesothelioma | “mesothelioma” | 77 | 71.6 | 55:22 | 3.9 | 37.7 | 42.9 | 15.6 |
| Mycosis fungoides | “mf” or “mycosis” or “fungoides” | 23 | 58.9 | 11:12 | 0 | 13.0 | 34.8 | 52.1 |
| Neuroendocrine | “neuroendocrine” or “merkel” or “carcinoid” | 268 | 67.2 | 150:118 | 2.6 | 62.3 | 28.4 | 6.7 |
| Ovary | “ovary” or “ovarian” | 256 | 62.3 | 0:256 | 2.0 | 61.3 | 33.2 | 3.5 |
| Pancreas | “pancreas” or “pancreatic” or “ampulla” | 286 | 65.0 | 153:133 | 2.8 | 54.6 | 31.8 | 10.8 |
| Prostate | “prostate” and “prostatic” | 193 | 72.4 | 193:0 | 3.1 | 63.2 | 23.8 | 9.8 |
| Renal | “kidney” or “renal” | 246 | 66.6 | 142:104 | 3.7 | 45.1 | 30.1 | 21.1 |
| Sarcoma | “sarcoma” | 140 | 63.8 | 69:71 | 2.1 | 40.7 | 23.6 | 33.6 |
| Thymoma | “thymoma” | 9 | 57.2 | 3:6 | 11.1 | 22.2 | 22.2 | 44.4 |
| Thyroid | “thyroid” | 68 | 61.3 | 18:50 | 4.4 | 49.0 | 20.6 | 26.5 |
| Urothelial | “bladder” or “urothelial” or “transitional” | 273 | 70.9 | 177:96 | 2.9 | 46.5 | 31.9 | 18.7 |
| Vulva or vagina | “vulva” or “vagina” | 85 | 64.4 | 0:85 | 2.3 | 44.7 | 31.8 | 21.2 |
| Adenocarcinoma | “adenocarcinoma” | 9575 | 69.1 | 4302:5273 | 3.2 | 33.7 | 34.5 | 28.6 |
| Poorly differentiated adenocarcinoma | [“poorly” and “differentiated”] and “adenocarcinoma” | 974 | 67.8 | 486:488 | 2.5 | 22.1 | 27.2 | 48.3 |
| Moderately differentiated adenocarcinoma | [“moderately” and “differentiated”] and “adenocarcinoma” | 676 | 69.1 | 304:372 | 2.5 | 36.8 | 38.6 | 22.0 |
| Well-differentiated adenocarcinoma | [“well” and “differentiated”] and “adenocarcinoma” | 278 | 71.5 | 114:164 | 4.7 | 49.6 | 38.1 | 7.6 |
| Mucinous adenocarcinoma | “mucinous” and “adenocarcinoma” | 226 | 69.7 | 111:115 | 3.5 | 51.3 | 34.1 | 11.1 |
| Squamous cell carcinoma | “squamous” or “SCC” or “SCCA” | 3102 | 70.5 | 1905:1197 | 2.3 | 26.4 | 40.8 | 30.5 |
| Poorly differentiated squamous cell carcinoma | [“poorly” and “differentiated”] and “squamous” or “SCC” or “SCCA” | 575 | 70.2 | 348:227 | 2.7 | 24.7 | 37.0 | 36.0 |
| Moderately differentiated squamous cell carcinoma | [“moderately” and “differentiated”] and “squamous” or “SCC” or “SCCA” | 508 | 71.6 | 312:196 | 0.6 | 24.2 | 44.3 | 30.9 |
| Well-differentiated squamous cell carcinoma | [“well” and “differentiated”] and “squamous” or “SCC” or “SCCA” | 71 | 68.6 | 42:29 | 1.4 | 16.9 | 54.9 | 26.8 |
| Adenosquamous | “adenosquamous” | 82 | 73.5 | 48:34 | 0 | 20.7 | 35.4 | 43.9 |
| Metastatic | “metastatic” | 3933 | 67.5 | 1944:1989 | 2.6 | 35.9 | 30.8 | 30.7 |
| Pleural fluid | [“pleural” and “fluid”] or [“pleural” and effusion”] | 2105 | 72.1 | 1025:1080 | 3.1 | 29.6 | 32.6 | 34.6 |
| Pericardial fluid | “pericardial” and “fluid” | 44 | 66.5 | 15:29 | 0 | 0 | 0 | 100 |
| Bone | “bone” | 2275 | 68.3 | 1246:1029 | 3.3 | 40.7 | 29.2 | 26.7 |
| Metastases in brain | “brain” and “metastatic” | 47 | 62.9 | 18:29 | 2.1 | 42.6 | 23.4 | 31.9 |
| Adrenal | “adrenal” | 549 | 67.7 | 307:242 | 3.6 | 27.5 | 33.9 | 35.0 |
aTumor type was assessed using a natural language search of submitted information for site and submitted clinical history. All cases may not be represented from larger data set due to ambiguous or missing information in submitted site/history