TABLE IV:

Glycemic metrics comparing the proposed method with the zone MPC developed in [7] (Protocol C)

Protocol C	Day 1			Day 2			Day 3
Metrics	Control	Proposed	p value	Control	Proposed	p value	Control	Proposed	p value
Day & night
% time <54 mg/dL	0.0 (0.0)	0.0 (0.0)	0.064	0.0 (0.0)	0.0 (0.0)	1.000	0.0 (0.0)	0.0 (0.0)	0.500
% time <70 mg/dL	0.0 (0.0)	0.0 (0.0)	0.397	0.0 (0.0)	0.0 (0.0)	0.096	0.0 (0.0)	0.0 (0.0)	0.001*
% time 70–180 mg/dL	66.3 (14.3)	70.5 (11.5)	<0.001*	84.7 (13.6)	85.8 (12.6)	<0.001*	56.1 (21.1)	64.8 (18.0)	<0.001*
% time >250 mg/dL	3.6 (10.8)	1.9 (7.1)	<0.001*	0.0 (0.0)	0.0 (0.0)	<0.001*	12.2 (17.2)	5.9 (13.4)	<0.001*
Mean BG (mg/dL)	159.0 (18.1)	153.8 (13.5)	<0.001*	148.9 (10.3)	146.1 (9.6)	<0.001*	180.6 (31.6)	166.4 (21.9)	<0.001*
SD BG (mg/dL)	47.7 (13.8)	45.6 (12.7)	<0.001*	27.7 (10.5)	28.4 (10.6)	<0.001*	49.6 (14.5)	45.3 (13.3)	<0.001*
Night time (0–6 AM)
% time <54 mg/dL	0.0 (0.0)	0.0 (0.0)	0.219	0.0 (0.0)	0.0 (0.0)	1.000	0.0 (0.0)	0.0 (0.0)	1.000
% time <70 mg/dL	0.0 (0.0)	0.0 (0.0)	0.010*	0.0 (0.0)	0.0 (0.0)	1.000	0.0 (0.0)	0.0 (0.0)	0.008*
% time 70–180 mg/dL	100.0 (0.0)	100.0 (0.0)	<0.001*	100.0 (0.0)	100.0 (0.0)	<0.001*	100.0 (7.5)	100.0 (0.0)	<0.001*
% time >250 mg/dL	0.0 (0.0)	0.0 (0.0)	1.000	0.0 (0.0)	0.0 (0.0)	1.000	0.0 (0.0)	0.0 (0.0)	0.143
Mean BG (mg/dL)	120.6 (9.0)	119.7 (8.2)	<0.001*	133.1 (10.8)	131.0 (9.8)	<0.001*	138.0 (17.8)	134.3 (12.6)	<0.001*
SD BG (mg/dL)	13.5 (7.3)	13.0 (7.3)	<0.001*	12.5 (5.7)	12.9 (6.2)	<0.001*	14.6 (8.3)	13.9 (6.9)	<0.001*
Mean BG at 7 AM (mg/dL)	122.0 (15.0)	121.0 (14.0)	<0.001*	140.5 (19.0)	136.0 (21.0)	<0.001*	140.5 (25.0)	135.0 (26.0)	<0.001*

Data in this table are shown as median (inter quartile range). Statistical significance is assessed by Wilcoxon signed-rank test. Statistically significant (p < 0.05) changes are highlighted in bold with asterisks.