Figure 2.

Noncellular enzymatic degradation, initiated by immersing hydrogels without hMSCs in a 0.3 mg/mL collagenase solution. (a) Bulk rheology measures the elastic moduli, G′, as a function of time. (b) Normalized elastic moduli, $G^{\prime }/G_0^{\prime }$, as a function of time. Enzymatic degradation is modeled using eq 3, resulting in an enzymatic kinetic constant, k* = 86.7 ± 0.71 M⁻¹ s⁻¹.