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. 2019 Sep 25;14(9):e0222588. doi: 10.1371/journal.pone.0222588

Fig 1. General structure of the 5’ portion of the human NEMO gene.

Fig 1

(A) Shown are the four 5’ alternative non-coding exons (1D, 1A, 1B, 1C) of the NEMO gene on chromosome X, as determined by Fusco et al. [19]. NEMO exon 1B has RNAPII, H3K4me3 and DNase hypersensitive site footprints in HEK 293 cells (https://www.encodeproject.org/experiments/ENCSR000DTU/; https://www.encodeproject.org/experiments/ENCSR000EJR/). (B) Downstream of the NEMO exon 1B transcription start site (arrow) is a sequence (red) that aligns with a consensus motif (above the red box) that is found near transcription start site of many genes [21].