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. Author manuscript; available in PMC: 2019 Sep 25.
Published in final edited form as: IEEE J Biomed Health Inform. 2015 Oct 26;20(6):1595–1607. doi: 10.1109/JBHI.2015.2483318

Fig. 9:

Fig. 9:

Image examples of nuclei detection algorithm. (a) Image with preliminary nuclei objects obtained from clustering (step 1 – Figure 8(c)). (b) Image closing to connect nuclei objects (step 2). (c) Image with hole filling to produce nuclei objects (step 3). (d) Image opening to separate nuclei objects (step 4). (e) Image with non-nuclei (small) objects eliminated (step 5).