Table 1:

Thermodynamic data from ITC for the binding of guests G0-G7 to hosts OA and TEMOA.^a

	OA				TEMOA
Guests	Kab M−1	∆Gc kcal/mol	∆Hd kcal/mol	–T∆Se kcal/mol	Kab M−1	∆Gc kcal/mol	∆Hd kcal/mol	–T∆Se kcal/mol
G0	1.47 E04	–5.68	–4.84	–0.84	2.81 E04	–6.06	–7.85	1.77
G1	2.57 E03	–4.65	–5.52	0.86	2.40 E04	–5.97	–8.25	2.27
G2	1.40 E06	–8.38	–12.07	3.69	9.82 E04	–6.81	–9.27	2.46
G3	6.21 E03	–5.18	–7.53	2.35	1.28 E04	–5.60	–8.86	3.25
G4	1.64 E05	–7.11	–6.92	–0.19	5.12 E05	–7.79	–8.87	1.08
G5	2.33 E03	–4.59	–5.31	0.71	1.13 E03	–4.16	–7.96	3.80
G6	4.37 E03	–4.97	–5.29	0.33	9.12 E03	–5.40	–6.19	0.79
G7	3.60 E04	–6.22	–7.44	1.23	1.07 E03	–4.13	–8.33	4.20

^a)25 ˚C, 50 mM sodium phosphate buffer, pH = 11.5.

^b)Errors in K_a were < 4% in all cases (see SI for specific values).

^c)Calculated error in ∆G is negligible due to the logarithmic relationship with K_a.

^d)Errors in ∆H were < 4% in all cases (see SI for specific values).

^e)Errors in –T∆S were < 14% in all cases (see SI for specific values).