Table 1:
Serum and urine measures of kidney disease status at study end
| 6 mo | 18 mo | 24 mo | ||||
|---|---|---|---|---|---|---|
| Sham | CKD | Sham | CKD | Sham | CKD | |
| Serum urea (mg/dL) | 87.9 ± 5.84 | 152 ± 15.8 | 73.5 ± 6.76 | 212 ± 15.9 | 76.3 ± 11.5 | 188 ± 21.9 |
| Age: NS | ||||||
| CKD: p < 0.001 | ||||||
| Age × CKD: NS | ||||||
| Urine urea (mg/dL) | 8.94E3 ± 1.36E3 | 5.39E3 ± 0.599E3 | 8.28E3 ± 1.05E3 | 5.55E3 ± 0.633E3 | 9.48E3 ± 0.792E3 | 5.52E3 ± 0.846E3 |
| Age: NS | ||||||
| CKD: p < 0.001 | ||||||
| Age × CKD: NS | ||||||
| Phosphate (mg/dL) | 9.22 ± 1.77 | 12.7 ± 0.682 | 9.63 ± 0.890 | 12.3 ± 0.960 | 9.53 ± 0.830 | 11.9 ± 0.324 |
| Age: NS | ||||||
| CKD: p = 0.001 | ||||||
| Age × CKD: NS | ||||||
| Calcium (mg/dL) | 9.43 ± 0.282 | 7.50 ± 1.37 | 8.25 ± 0.554 | 9.16 ± 0.791 | 7.14 ± 1.14 | 8.78 ± 0.285 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| Parathyroid hormone (mg/dL) | 165 ± 51.9 | 302 ± 113 | 180 ± 42.1 | 464 ± 76.3 | 228 ± 38.5 | 490 ± 114 |
| Age: NS | ||||||
| CKD: p = 0.002 | ||||||
| Age × CKD: NS | ||||||
Data are presented as mean +/− standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column. Serum urea, phosphate, and calcium were measured for 6 mo /Sham (n = 6), 6 mo/CKD (n = 7), 18 mo/Sham (n = 8), 18 mo/CKD (n = 10), 24 mo/Sham (n = 8), 24 mo/CKD (n = 8). PTH was assessed for 6 mo/Sham (n = 5), 6 mo/CKD (n = 5), 18 mo/Sham (n = 4), 18 mo/CKD (n = 6), 24 mo/Sham (n = 5), 24 mo/CKD (n = 5). Urine urea was measured for 6 mo /Sham (n = 6), 6 mo/CKD (n = 7), 18 mo/Sham (n = 7), 18 mo/CKD (n = 9), 24 mo/Sham (n = 7), 24 mo/CKD (n = 6).