Table 2:

Cortical microarchitecture from microCT

	6 mo		18 mo		24 mo
	Sham n = 5	CKD n = 7	Sham n = 8	CKD n = 9	Sham n = 8	CKD n = 8
BV/TV	0.920 ± 0.00186	0.908 ± 0.00427	0.916 ± 0.00189	0.903 ± 0.00378	0.900 ± 0.00557	0.890 ± 0.00472
Age: p < 0.001
CKD: p = 0.001
Age × CKD: NS
BA/TA	0.468 ± 0.00824	0.438 ± 0.0120	0.407 ± 0.00746	0.371 ± 0.00873	0.388 ± 0.00942	0.335 ± 0.00744
Age: p < 0.001
CKD: p < 0.001
Age × CKD: NS
Ct.Po	8.05 ± 0.186	9.21 ± 0.427	8.44 ± 0.189	9.72 ± 0.378	9.98 ± 0.557	11.0 ± 0.472
Age: p < 0.001
CKD: p < 0.001
Age × CKD: NS
Ct. Th (mm)	0.202 ± 0.00186	0.187 ± 0.00525	0.189 ± 0.00385	0.168 ± 0.00473	0.198 ± 0.00610	0.162 ± 0.00427
Age: p = 0.004
CKD: p < 0.001
Age × CKD: NS
TMD (mg HA /cm3)	1.04E3 ±9.13	1.02E2 ± 4.08	1.06E2 ± 6.58	1.04E2 ± 6.16	1.07E2 ± 2.82	1.04E2 ± 6.42
Age: p = 0.001
CKD: p < 0.001
Age × CKD: NS
IML(mm4)	0.138 ± 0.00804	0.132 ± 0.00864	0.178 ± 0.0137	0.138 ± 0.00533*	0.240 ± 0.00844	0.175 ± 0.0145*
Age: p < 0.001
CKD: p < 0.001				p = 0.004		p < 0.001
Age × CKD: p < 0.05				−22.5%		−27.1%
pMOI	0.446 ± 0.0221	0.406 ± 0.0200	0.542 ± 0.0366	0.433 ± 0.0145	0.683 ± 0.0282	0.535 ± 0.0374
Age: p < 0.001
CKD: p < 0.001
Age × CKD: NS

Data are presented as mean +/− standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column. Post-hoc testing was performed for measures with a significant interaction between age and CKD.

^*Indicates significant difference between Sham and CKD at the same age (p < 0.017, Bonferroni-adjusted critical α), while percent differences between Sham and CKD are noted when p < 0.05.