Table 4:
6 mo | 18 mo | 24 mo | ||||
---|---|---|---|---|---|---|
Sham n = 5 |
CKD n = 7 |
Sham n = 8 |
CKD n = 9 |
Sham n = 8 |
CKD n = 8 |
|
Stiffness (N/mm) | 99.2 ± 5.11 | 88.5 ± 4.68 | 91.5 ± 6.03 | 64.4 ± 6.39 | 83.2 ± 6.93 | 62.7 ± 6.23 |
Age: p = 0.009 | ||||||
CKD: p < 0.001 | ||||||
Age × CKD: NS | ||||||
Modulus (GPa) | 7.44 ± 0.237 | 7.22 ± 0.266 | 5.53 ± 0.307 | 4.95 ± 0.360 | 3.92 ± 0.240 | 3.69 ± 0.186 |
Age: p < 0.001 | ||||||
CKD: NS | ||||||
Age × CKD: NS | ||||||
Yield Stress (MPa) | 132 ± 10.7 | 127 ± 4.74 | 82.2 ± 6.51 | 76.0 ± 10.2 | 65.9 ± 7.46 | 66.1 ± 4.74 |
Age: p < 0.001 | ||||||
CKD: NS | ||||||
Age × CKD: NS | ||||||
Maximum Stress (MPa) | 163 ± 3.55 | 154 ± 3.88 | 110 ± 3.62 | 112 ± 6.53 | 97.4 ± 5.99 | 90.5 ± 4.81 |
Age: p < 0.001 | ||||||
CKD: NS | ||||||
Age × CKD: NS | ||||||
Work to Fracture (mJ) | 6.40 ± 1.48 | 4.47 ± 0.735 | 8.51 ± 1.25 | 3.87 ± 1.22 | 5.11 ± 1.89 | 4.53 ± 1.03 |
Age: p > 0.05 | ||||||
CKD: p = 0.041 | ||||||
Age × CKD: NS | ||||||
Toughness (MJ/m3) | 7.54 ± 1.86 | 4.87 ± 0.582 | 8.43 ± 1.78 | 4.39 ± 1.51* | 3.03 ± 0.982 | 5.86 ± 1.10 |
Age: NS | ||||||
CKD: NS | p = 0.022 | p = 0.046 | ||||
Age × CKD: p = 0.011 | −47.9% | +93.9% | ||||
Post-Yield Displacement (mm) | 0.342 ± 0.0954 | 0.195 ± 0.0216 | 0.947 ± 0.227 | 0.535 ± 0.226 | 0.250 ± 0.0672 | 0.481 ± 0.117 |
Age: NS | ||||||
CKD: NS | ||||||
Age × CKD: NS | ||||||
FEA Stiffness (N/mm) | 9680 ± 305 | 8750 ± 595 | 7780 ± 254 | 6440 ± 289 | 7840 ± 503 | 6550 ± 454 |
Age: p < 0.001 | ||||||
CKD: p < 0.001 | ||||||
Age × CKD: NS |
Data are presented as mean +/− standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column. Post-hoc testing was performed for measures with a significant interaction between age and CKD.
Indicates significant difference between Sham and CKD at the same age (p < 0.017, Bonferroni-adjusted critical α), while percent differences between Sham and CKD are noted when p < 0.05.