Table 5:
Mean microscale material properties from nanoindentation and Raman spectroscopy
| 6 mo | 18 mo | 24 mo | ||||
|---|---|---|---|---|---|---|
| Sham n = 6 |
CKD n = 6 |
Sham n = 6 |
CKD n = 6 |
Sham n = 6 |
CKD n = 6 |
|
| Er (GPa) | 29.2 ± 0.594 | 29.3 ± 0.567 | 29.0 ± 0.462 | 27.0 ± 0.872 | 26.5 ± 0.918 | 26.7 ± 0.962 |
| Age: p = 0.006 | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| v1 phosphate: (proline+hydroxyproline) | 19.2 ± 3.69 | 17.0 ±2.97 | 20.2 ± 1.74 | 28.0± 6.69 | 21.3 ± 3.71 | 14.4 ± 1.45 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| Carbonate:phosphate | 9.35E-2 ± 0.818E-2 | 10.0E-2 ± 1.07E-2 | 10.1E-1 ± 0.957E-2 | 10.1E-2 ± 0.997E-2 | 10.6E-2 ± 0.944E-2 | 9.91E-2 ± 0.905E-2 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| Crystallinity | 5.78E-2 ± 6.16E-4 | 5.83E-2 ± 8.54E-4 | 5.713E-2 ± 4.89E-4 | 5.81E-2 ± 7.66E-4 | 5.64E-2 ± 3.75E-4 | 5.79E-2 ± 8.87E-4 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| stdev Er (GPa) | 3.47 ± 0.108 | 3.40 ± 0.128 | 4.34 ± 0.252 | 3.48 ± 0.278 | 4.48 ± 0.107 | 4.12 ± 0.359 |
| Age: p = 0.004 | ||||||
| CKD: p = 0.032 | ||||||
| Age × CKD: NS | ||||||
| stdev v1 phosphate: (proline+hydroxyproline) | 10.8 ± 2.83 | 11.0 ± 3.38 | 8.87 ± 1.05 | 19.5 ± 6.73 | 15.5 ± 5.12 | 5.18 ± 0.819 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| Stdev carbonate:phosphate | 11.0E-3 ± 0.517E-3 | 12.0E-3 ± 1.23E-3 | 9.46E-3 ± 0.860E-3 | 11.3E-3 ± 1.53E-3 | 10.3E-3 ± 0.742E-3 | 13.4E-3 ± 1.74E-3 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| stdev crystallinity | 1.48E-3 ± 0.158E-3 | 1.17E-3 ± 0.0930E-3 | 1.52E-3 ± 0.171E-3 | 1.09E-3 ± 0.154E-3 | 1.14E-3 ± 0.121E-3 | 1.19E-3 ± 0.0760E-3 |
| Age: NS | ||||||
| CKD: p = 0.048 | ||||||
| Age × CKD: NS | ||||||
Data are presented as mean +/− standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column.