Table 6:

Tissue and collagen strain from SAXS

	6 mo		18 mo		24 mo
	Sham n = 5	CKD n = 7	Sham n = 4	CKD n = 7	Sham n = 5	CKD n = 4
Modulus (GPa)	12.1 ± 2.55	13.2 ± 2.21	10.3 ± 1.05	14.7 ± 1.58	10.5 ± 1.89	12.5 ± 3.29
Age: NS
CKD: NS
Age × CKD: NS
Tissue yield stress (MPa)	56.8± 0.892	50.9 ± 2.80	48.7 ± 2.83	38.9 ± 6.97	39.6 ± 5.87	44.3 ± 3.34
Age: p = 0.046
CKD: NS
Age × CKD: NS
Tissue yield strain	0.743 ± 0.0900	0.631 ± 0.0528	0.681 ± 0.0313	0.416 ± 0.0569	0.551 ± 0.101	0.559 ± 0.0718
Age: NS
CKD: NS
Age × CKD: NS
Tissue maximum stress (MPa)	74.3 ± 5.42	61.6 ± 2.71	58.6± 3.28	44.1± 8.64	47.0 ± 6.72	52.3 ± 5.26
Age: p = 0.011
CKD: p > 0.05
Age × CKD: p > 0.05
Tissue maximum strain	2.13 ± 0.485	1.21 ± 0.102	1.45 ± 0.286	0.784 ± 0.186	0.958 ± 0.165	0.111 ± 0.235
Age: p = 0.033
CKD: p = 0.030
Age × CKD: NS
Collagen strain at yield strain	0.219 ± 0.0277	0.272 ± 0.0508	0.208 ± 0.0389	0.180 ± 0.0403	0.171 ± 0.0575	0.199± 0.0445
Age: NS
CKD: NS
Age × CKD: NS
Collagen strain at maximum strain	0.465± 0.0899	0.354 ± 0.0520	0.267 ± 0.0485	0.222 ± 0.0625	0.168 ± 0.0575	0.331 ± 0.0933
Age: p = 0.033
CKD: p > 0.05
Age × CKD: p > 0.05
Percent collagen strain at yield	30.4 ± 2.96	45.6 ± 9.78	30.4 ± 5.23	35.4 ± 5.66	24.5 ± 6.14	34.7 ± 7.43
Age: NS
CKD: NS
Age × CKD: NS
Percent collagen strain at maximum strain, %ColMax	23.0 ± 3.00	31.1 ± 4.32	19.8 ± 4.08	28.4 ± 4.38	14.7 ± 2.75	32.4 ± 11.8
Age: NS
CKD: p = 0.014
Age × CKD: NS

Data are presented as mean +/− standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column.