Table 7:
Collagen crosslink assessments
| 6 mo | 18 mo | 24 mo | ||||
|---|---|---|---|---|---|---|
| Sham n = 4 |
CKD n = 7 |
Sham n = 6 |
CKD n = 9 |
Sham n = 7 |
CKD n = 8 |
|
| HP (mol / mol collagen) | 2.17 ± 0.39 | 2.15 ± 0.28 | 2.44 ± 0.25 | 2.57 ± 0.19 | 2.97 ± 0.25 | 2.29 ± 0.25 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| LP (mol / mol | 0.29 ± 0.02 | 0.23 ± 0.02 | 0.30 ± 0.02 | 0.30 ± 0.02 | 0.31 ± 0.01 | 0.28 ± 0.01 |
| collagen) | ||||||
| Age: NS | ||||||
| CKD: p = 0.056 | ||||||
| Age × CKD: NS | ||||||
| Pentosidine (mol / mol collagen) | 1.39 ± 0.43 | 1.57 ± 0.26 | 2.42 ± 0.75 | 2.11 ± 0.53 | 2.59 ± 0.59 | 2.62 ± 0.35 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
| Total fluorescent AGEs | 188 ± 12.0 | 204 ± 18 | 321 ± 89.3 | 206 ± 34.0 | 242 ± 55.9 | 219 ± 33.6 |
| Age: NS | ||||||
| CKD: NS | ||||||
| Age × CKD: NS | ||||||
Data are presented as mean +/− standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column.