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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Neurobiol Dis. 2019 Mar 27;127:390–397. doi: 10.1016/j.nbd.2019.03.029

Fig. 1. eNMDAR activity triggers a signaling cascade to inactivate TSC2, which is attenuated by memantine.

Fig. 1.

(A) Western blots showing that eNMDAR stimulation increased phosphorylation/activation of the p38 MAPK/ MAPKAPK2/TSC2/mTORC1/S6K1 cascade. Blockade of eNMDARs with the eNMDAR antagonist memantine (10 μM) reduced this signaling. This experiment was replicated 4 times with similar results and quantified in panel b. (b) Quantification of immunoblots by unpaired t-test; mean ± s.e.m., n = 4, *P < 0.05 (Mem, memantine (c) Model of inhibition of the Tsc pathway after eNMDAR stimulation.