TABLE 1.

Correlations between IL-8, IFN-γ, IP-10, and IL-17A induced by PPD-B or CE^a

Protein	Correlation coefficient (Spearman’s r)
	PPD-B-stimulated plasma				CE-stimulated plasma
	IL-8	IFN-γ	IP-10	IL-17A	IL-8	IFN-γ	IP-10	IL-17A
IL-8		0.75*	0.63*	0.54*		0.63*	0.53*	0.48*
IFN-γ	0.75*		0.63*	0.61*	0.63*		0.62*	0.52*
IP-10	0.63*	0.63*		0.47*	0.53*	0.62*		0.44*
IL-17A	0.54*	0.61*	0.47*		0.48*	0.52*	0.44*

^aCorrelation coefficients were determined using Spearman’s two-tailed correlation test. *, P < 0.001, significant correlation. Comparisons included all individuals and all treatments (n = 61 [21 bTB_PCR-P + 21 bTB_PCR-N + 19 NC]). bTB_PCR-P, 21 cattle from a bTB-prevalent dairy farm positive for bTB by TST, CET-ST, IGRA, CE-based IGRA, and nested PCR; bTB_PCR-N, 21 cattle from a bTB-prevalent dairy farm positive for bTB by TST, CET-ST, IGRA, and CE-based IGRA but negative by nested PCR; NC, 19 cattle from a bTB-free dairy farm determined to be M. bovis negative by TST, CET-ST, IGRA, CE-based IGRA, and nested PCR. Whole blood was collected and stimulated with PPD-B or CE for 24 h. Plasma was harvested to measure the levels of cytokines using commercial kits.