TABLE 2.

Sensitivities and specificities of clinical laboratory tests

Test	Sensitivity (%)	Specificity (%)	Reference(s)
Nonspecific CSF biomarkers
14-3-3	61–95	40–92	16–18
t-tau	87–90	67–75	16, 18
t-tau/p-tau ratio	94	86	18
NSE	80	83–92	18, 20–22
S100B
sCJD	94	85	22
vCJD	78	76	26
gCJD	20–92		27
Alpha-synuclein	93–98	96–97	28–30
Specific biomarkers
CSF RT-QuIC (2nd generation)	92–97.2	98.5–100	34, 35
Brain biopsy PrPSc Western blotting	20–60		39