TABLE 1.

Targeted total plasma concentrations for antibiotic regimens in critically ill patients^a

Antibiotic	Dosing regimenb	Concentration (μg/ml) at:
		Peak	Midpoint	Trough
Meropenem	2 g q8h (3-h infusion)	40	20	5
Imipenem	500 mg q6h (0.5-h infusion)	25	3	1
Levofloxacin	750 mg q24h (1.5-h infusion)	13	3	1.5
Cefazolin	1 g q8h (0.5-h infusion)	108	13	3
Cefepime	2 g q8h (0.5-h infusion)	105	33	21
Piperacillin-tazobactam	4.5g (4 g piperacillin-0.5 g tazobactam) q6h (0.5-h infusion)	177	42	12

^aPharmacokinetics were previously reported for meropenem (12), imipenem (13), levofloxacin (14), cefazolin (15), cefepime (16), and piperacillin-tazobactam (17) (target concentrations were based on the piperacillin component).

^bq8h, every 8 h; q6h, every 6 h; q24h, every 24 h.