TABLE 3.
Observed antibiotic concentrations in whole blood before inoculation into blood culture bottlesa
| Antibiotic | Mean observed ± SD (target) (μg/ml) fora
: |
||
|---|---|---|---|
| Peak | Midpoint | Trough | |
| Meropenem | 21.5 ± 2.9 (20) | 11.2 ± 3.2 (10) | 4.9 (2.5) |
| Imipenem | NT | NT | NT |
| Levofloxacin | NT | NT | NT |
| Cefazolin | 60.2 ± 3.4 (54) | 7.9 ± 0.4 (6.5) | 1.8 ± 0.2 (1.5) |
| Cefepime | 49.0 ± 1.3 (52.5) | 12.4 ± 0.3 (16.5) | 9.0 ± 0.9 (10.5) |
| Piperacillin | 76.5 ± 2.75 (88.5) | 20.5 ± 2.2 (21) | 6.0 ± 0.9 (6) |
a
Data are presented as mean ± standard deviation for all antibiotic concentrations (μg/ml) except the meropenem trough where a single observation was tested. Target whole-blood concentration was determined as 1/2 target plasma concentration based on the assumption of 50% hematocrit of blood from the healthy volunteers.