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. 2019 Jun 12;13(5):367–376. doi: 10.4162/nrp.2019.13.5.367

Fig. 4. Histological images of the insulin- and glucagon-immunoreactive cells in the pancreas and all cells were immunostained by the avidin-biotin-peroxidase complex.

Fig. 4

(A) Intact control: 10 mL/kg of distilled water orally administered mice with the NFD supply. (B) Diabetes control: 10 mL/kg of distilled water orally administered mice with the HFD supply. (C) Metformin: 250 mg/kg of metformin orally administered mice with the HFD supply. (D) BHBe 400: 400 mg/kg of BHe orally administered mice with the HFD supply. (E) BHBe 200: 200 mg/kg of BHBe orally administered mice with the HFD supply. (F) BHBe 100: 100 mg/kg of BHBe orally administered mice with HFD supply. NFD, Normal pellet diet; HFD, 45% kcal high-fat diet; IS, Pancreatic islet; BHB, Blue honeyberry; BHBe, lyophilized powder of the BHB extract by enzyme; Scale bars = 80 µm.