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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Aug 29;39(10):2014–2027. doi: 10.1161/ATVBAHA.119.313034

Figure 6.

Figure 6.

Calpain inhibition and IL-19 reduce stress granule formation in human VSMCs. (A) Quantification of stress granules in human VSMCs unstimulated or pretreated with the calpain inhibitor zLLal prior to stimulation with clotrimazole. (B) Quantification of stress granules in human VSMCs untreated or pretreated with IL-19 prior to stimulation with clotrimazole (n=50). (C) Immunostaining for PABP (purple), HuR (red), and FXR1 (green) in human VSMCs untreated or pretreated with IL-19 prior to stimulation with clotrimazole. (D) Western blot analysis of total and phospho-eIF-2α in VSMCs untreated or pretreated with IL-19 prior to stimulation with clotrimazole. Data are the mean of 3 independent experiments. (E) Quantification of stress granules in human VSMCs untreated or pretreated with IL-19 prior to stimulation with oxLDL (n=50). (F) Western blot analysis of total and phospho-eIF-2α in VSMCs untreated or pretreated with IL-19 prior to stimulation with oxLDL. Data are the mean of 3 independent experiments. *P≤0.05, ** P≤0.01, or *** P≤0.001.