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. Author manuscript; available in PMC: 2019 Sep 25.
Published in final edited form as: Curr Top Med Chem. 2019;19(16):1381–1398. doi: 10.2174/1568026619666190709101449

Fig. (2). A cross-section of the 5-HT2CR signaling webs initiated by 5-HT binding to the orthosteric site is presented.

Fig. (2).

Activation of Gαq/11 promotes phospholipase Cβ (PLCβ) mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol-1,4,5-triphosphate (IP3). IP3 promotes release of intracellular calcium (Cai2+) while DAG binds to downstream effector protein kinase C (PKC).