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. Author manuscript; available in PMC: 2019 Sep 25.
Published in final edited form as: Curr Top Med Chem. 2019;19(16):1381–1398. doi: 10.2174/1568026619666190709101449

Fig. (3). A schematic presentation of the proposed 5-HT2CR modulation of limbic-corticoaccumbens circuit is represented.

Fig. (3).

Serotonin (5-HT) neurons originating from the dorsal raphe nuclei innervate GABA interneurons in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and the ventral tegmental area (VTA). Inhibitory GABAergic neurons facilitate decreased dopaminergic neuronal firing in the VTA both directly and indirectly. 5-HT2CR localizes to neurons within each of the nodes in this circuitry.