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. Author manuscript; available in PMC: 2019 Sep 25.
Published in final edited form as: Curr Top Med Chem. 2019;19(16):1381–1398. doi: 10.2174/1568026619666190709101449

Fig. (9). A new generation of 5-HT2CR PAMs has emerged.

Fig. (9).

The lead compounds from recent 5-HT2CR PAM discovery projects include VA012 (25) [142], 26 [143], and CYD-1–79 (27) [121] respectively. The CLogPs are reported to demonstrate that elevated lipophilicity is common among these newly discovered 5-HT2CR PAMs.