Table 1.
Blocking VWF binding with ARC1779 enhanced the post-transfusion recovery and survival of refrigerated WT platelets.
| Platelets (108/10g) | Recovery (%) | Survival (T1/2; hour) |
|---|---|---|
| Fresh WT platelets | 100 ± 11.71 | 43.89 ± 5.23 |
| Refrigerated WT platelets | 63.78 ± 0.81 (**) | 28.16 ± 0.86 (*) |
| Refrigerated WT platelets with ARC1779 | 76.71 ± 5.51 | 31.45 ± 2.37 |
The indicated platelets were transfused into WT mice (108/10g), and one hour later the recovery and half-life time (T1/2) of the transfused platelets were measured. The recovery of fresh WT platelets was considered as 100%. As indicated, the recovery of ARC1779 treated refrigerated WT platelets was higher than those without ARC1779 (n=6). Statistical analysis was performed by 1-way ANOVA.
*
, P < 0.05
**
, P < 0.01.