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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: J Immunol. 2019 Sep 6;203(7):1882–1896. doi: 10.4049/jimmunol.1900597

Figure 1. MHC class I, AgR, and catalytic proteasome β-subunit genes are found in the human and especially Xenopus major and minor MHC paralogous regions.

Figure 1.

The location of MHCpara marker genes correspond well between the human and Xenopus genomes. Two minor MHCpara are also shown since these regions contain significant marker genes (e.g. PSMB5) and other paralogues (e.g. TAPBPL) and thus harbor remnants of the ancestral linkage. Marker, or hallmark, genes are indicated in red and psmb genes in light blue. MHC class I/II, AgR, and NCR3 homologs are shown in green, blue, and purple, respectively. A VLR homolog, GP1BB is also shown with a grey box. Corresponding chromosomes in human and Xenopus are shown side-by-side. Natural killer receptor complexes (NKC, LRC) also map in minor MHCpara. Note that both minor MHCparas shown in this figure are likely derived from the human chr 19 precursor (see Fig 6).