Table I.
Chromosomal locations of genes in human and Xenopus genomes
| MHC and MHC paraglogues | |||||||
|---|---|---|---|---|---|---|---|
| MHC para. | Genes | Human chr. | X. laevis chr. | Scaffold (v7.1) |
Position (v7.1) | FISHed BAC |
Position (v9.1) |
| MHC-6 | TAPBP | 6p21.3 | 8Lq14-21 | 50694 | 6954053..6969886 | 108L10 | 50739635..50755022 |
| RXRB | 6p21.3 | 8Lq14-21 | 50694 | 7102020..7117938 | 106L10 | 50887807..50903520 | |
| PSMB8 | 6p21.3 | 8Lq21 | 75398 | 274622..283843 | 290K18 | 78508537..78523720 | |
| PSMB9 | 6p21.3 | 8Sq21 | 12933 | 4797175..4812351 | 044A14 | 78508537..78523720 | |
| PBX2 | 6p21.3 | 8Lq21 | 75398 | 378082..396079 | 114D22 | 51636291..51653761 | |
| NOTCH4 | 6p21.3 | 8Lq21 | 75398 | 337685..353721 | 114D22 | 59569525..51611344 | |
| C4 | 6p21.33 | 8Lq21 | 75398 | 475934..520806 | 114D22 | 51733637..51778496 | |
| PSMB10 | 16q22.1 | 8Lq21 | 75398 | 524686..539832 | 114D22 | 51782368..51796858 | |
| MHCpara-1 | NOTCH2 | 1p13-p11 | 4Lq25 | 78978 | 84826..126901 | 055J23 | 110037275..110044215 |
| PBX1 | 1q23 | 4Lq24 | 47606 | 5480539..5556446 | 036M06 | 99325939..99347128 | |
| RXRG | 1q22-q23 | 4Lq25 | 78978 | 1407934..1480769 | 055J23 | 111399108..111408361 | |
| MHCpara-9 | NOTCH1 | 9q34.3 | 8Lp12 | 37448 | 2529375..2559128 | 030B08 | 4177800..4228940 |
| RXRA | 9q34.3 | 8Lp* | 255149 | 96949..211615 | NA | 5266355..5268209 | |
| PBX3 | 9q33.3 | 8Lp11 | 403228 | 523205..572639 | 020L15 | 11095878..11257315 | |
| PSMB7 | 9q33.3 | 8Lp11-12 | 3586 | 2248619..2282130 | 227M14 | 9754478..9780669 | |
| C5 | 9q33.2 | 8Lp* | 86205 | 1227102..1317602 | NA | 5816244..5865712 | |
| MHCpara-19 | NOTCH3 | 19p13.2 | 3Lq33-34 | 171831 | 677258..734233 | 079J11 | 125881103..125938078 |
| C3 | 19p13.3 | 3Lq34-35 | 175714 | 455613..739326 | 322O09 | 134274206..134300156 | |
| PSMB6 | 17p13.2 | 3Lq35 | 16004 | 50127..57691 | 017J04 | 139511604..139519183 | |
| PBX4 | 19p13.11 | NA | NA | NA | NA | NA | |
| MHCpara-14 (minor) |
IgLσ | NA | 1Lq12 | 39437 | 417923..418230 | 031N23 | 98280301..98295182 |
| TRA | 14q11.2 | 1Lq15 | 29869 | 458946..459559 | 039F04 | 140207982..140211379 | |
| TRD | 14q11.2 | 1Lq15 | 272406 | 116704..184681 | 130J21 | 140946814..140951210 | |
| IgHMC | 14q32-33 | 1Lq14-15 | 13576 | 6811972..7160435 | 312E22 | 139040662..139059333 | |
| PSMB5 | 14q11.2 | 1Lq14 | 13576 | 6389514..6394129 | 244A12 | 138627523..138632499 | |
| IgLλ | 22q11.22 | 1Lq21 | 162663 | 1..140765 | 159H19 | 153417276..153418351 | |
| MHCpara-12 (minor) |
TAPBPL | 12p13.31 | 7Lp23-24 | 79772 | 4980784..7959403 | 225A12 | 7950550..7960609 |
| LAG3 | 12p13.31 | 7Lp23-24 | 79772 | 5304485..5317904 | 225A12 | 7593489..7606908 | |
| CD4 | 12p13.31 | 7Lp23-24 | 79772 | 5359817..5371805 | 225A12 | 7539588..7551576 | |
| A2M | 12p13.31 | 7Lp24* | 131666 | 1275208..1307453 | 307G18 | 5334645..5366890 | |
| CLEC2B | 12p13.31 | 7Lp24* | 131666 | 693899..709661 | 307G18 | 5932418..5948215 | |
| Class Ia/Ib and AgR genes | |||||||
| Gene | Human chr | X. laevis chr. | Scaffold (v.7.1) |
Position (v7.1) | FISHed BAC |
Position (v9.1) | Domains |
| MHC class I and class I-like | |||||||
| 112 | 1Lq12 | 72621 | 122476..126293 | 085N05 | 102130692..102139541 | a1,2,3; a1,2; a2 | |
| 145 | 8Lq25 | 265107 | 1565727..1581290 | 012C13 | 87117299..87129697 | a1,2,3 | |
| Class Ia | 6p21.3 | 8Lq21 | 75396 | 164448..242219 | 290K18 | 51482854..51498908 | a1,2,3 |
| XNC | 8Lq31-32 | 26819 | 3427830..3826756 | 156D07 | 110198845..110862792 | a1,2,3 | |
| 16004 | 3Lq35 | 16004 | 123032..130911 | 017J04 | 139582763..139592397 | a1,2,3 | |
| CD1 | 1q22-23 | a1,2,3 | |||||
| MR1 | 1q25.3 | a1,2,3 | |||||
| FCGRT | 19q13.33 | a1,2,3 | |||||
| PROCR | 20q11.2 | a1,2 | |||||
| ZAG | 7q22.1 | a1,2,3 | |||||
| ULBP RAET | 6q25 | a1,2,3 | |||||
| AgR-like | |||||||
| 1310 | 8Lp12 | 127590 | 359968..365248 | 209G21 | 1072952..1075438 | VC | |
| 258 | 8Lq14-21 | 50694 | 22116..25167 | 106L10 | 43808224..43815003 | VC | |
| 406 | Lost? (1q22) | 8Lq31-32 | 115163 | Multigene family 221846..1754674 | 033B12 | 104468021..106003445 | VC |
| PTCRA | 6p21.1 | C (loss of V?) | |||||
| IgLκ | 2p12 | 1Lp32-34 | 109418 3467 | 2725506..2725994 177260..183220 | 213L05 146J08 | 9199747..9212091 | VC |
| TCRβC | 7q34 | 7Lp23-24 | 230427 | 307269..307610 | 191H14 | 315991...316317 | VC |
| TCRγC | 7P14 | 6Lp12-13 | 19169 | 498099..551608 | 045F01 | 62074212..62074523 | VC |
| NKp30 homologue | |||||||
| NKp30 | 6p21.3 | 4Lq25 | 35524 | Multigene family 2568835..2569428 | 166F02 | 118024408..118452984 | V |
| XMIV | (6p21.3) | 8Lq21 | 75398 | Multigene family 1530600..1631611 | 154P18 | 52754412..52854193 | V |
*
Mapping location based on v9.1.