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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Br J Dermatol. 2019 Jul 7;181(6):1146–1155. doi: 10.1111/bjd.17917

Figure 2. Susceptibility loci identified in published genome-wide association studies.

Figure 2.

The nearest genes to significant loci for melanoma, cutaneous squamous cell carcinoma (cSCC), and basal cell carcinoma (BCC) are shown. Overlapping regions indicate loci identified in more than one tumour type. Loci involved in key pathways are highlighted as follows: skin pigmentation, red; immune regulation, blue; cell cycle progression, gold. For cSCC and BCC, loci at 2p22.3 (cSCC) and 21q22.3 (BCC) include long non-coding RNA’s. For melanoma, 1q21.3 is a region spanning 10 genes, including ARNT/SETDB1 and 1q42.12 is a region including the DNA repair gene PARP. The loci at 10q25.1 lies between the SORCS1 and SORCS3 genes, which are involved in vacuolar protein production.