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. 2019 Sep 25;10:4358. doi: 10.1038/s41467-019-12298-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — High-fat diet enhances MYC-driven transcriptional changes at H4K20me1 dynamic genes. a Global chromatin profiling identifies distinct chromatin-signature profiles in MYC-overexpressing DLP and VP lobes (histone marks levels relative to the DLP, VP and AP CTD_WT median values; MYC vs. WT comparisons, unpaired t test; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; Supplementary Data 6). b HFD enhances H4K20 hypomethylation triggered by MYC (MYC vs. WT and HFD_MYC vs. CTD_MYC comparisons, unpaired t test; *P < 0.05, **P < 0.01, ****P < 0.0001). c H4K20me0 levels relative to the CTD_WT condition (fold change; unpaired t test, mean ± SEM; **P < 0.01, ***P < 0.001, ****P < 0.0001). d H4K20me1 dynamic regions across all murine gene bodies relative to the CTD_WT condition. e HFD enhances the effect of MYC on gene expression at H4K20me1 dynamic regions that were lost (top, n = 2508 genes) or gained (bottom, n = 3208 genes; paired t test, median, whiskers ± min/max)