Fig. 4.

A saturated fat-induced MYC signature is associated with lethal prostate cancer. a, b GSEA analysis (Hallmark) revealed that high animal fat and high saturated fat intake enriches for the MYC_targets_V1 gene set (a, P < 0.05 and FDR < 0.1), as represented by the enrichment plot (b) in the HSPH/PHS cohorts. c The lethality for every 0.1 unit increase of MYC score was significantly elevated among patients with high saturated fat intake compared with those with low saturated fat intake. d High expression of the saturated fat-induced MYC signature is significantly associated with reduced metastatic-free survival (T3) in four independent cohorts (TJU/JHMI-I/Mayo Clinic/Cedar-Sinai cohorts, n = 631). e Short-term dietary intervention (HFD switch to CTD) dampens the HFD-induced MYC transcriptional activity in MYC-driven murine prostate cancer. f Graphical summary